The molecular identity that underlies the M-current was discovered as a result of identification of mutations in human potassium channel subunits referred to as KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) from idiopathic generalized epilepsy patients [36,37]. This evidence concerns the gene KCNQ2 and idiopathic generalized epilepsy.