RAI1 and Global developmental delay: Alterations in the RAI1 gene have been associated with Smith-Magenis and Potocki-Lupski Syndromes whose clinical presentation includes autistic features, obsessive-compulsive behaviors, attention deficit, developmental delay, mental retardation, EEG abnormalities, sleep disturbances, self-injurious and maladaptive behaviors, among others [19-21].