In addition to this, RAI1 gene was associated with spinocerebellar ataxia (SCA2) [26], neuroleptic response in patients with schizophrenia [27], neurobehavioral traits manifested in SMS patients with RAI1 loss-of-function alleles [33-46] and non syndromic autism [28]. Here, RAI1 is linked to spinocerebellar ataxia type 2.