A missense mutation (M9R) in TPM3 causes nemaline myopathy and reduces affinity of tropomyosin with tropomodulin, a pointed-end capping protein, thereby potentially influencing the actin dynamics at the pointed ends [Akkari et al., 2002; Ilkovski et al., 2008; Gokhin et al., 2010] (see below for functions of Tmod). This evidence concerns the gene TPM3 and nemaline myopathy.