In addition to initial findings in cultured hepatocellular carcinoma, we now show that Enz inhibits the in vitro migration and invasion of NSCLC cells (Guo et al, 2009), and that EGF-induced invasion is countered by Enz, which is a major pathway in NSCLC progression (Nikolova et al, 2009). The gene discussed is EGF; the disease is hepatocellular carcinoma.