HIF1A and non-small cell lung carcinoma: In addition to the u-PAR, an overexpression of further molecules such as hypoxia-inducible factor 1α (HIF1α), a transcription factor, and vascular endothelial growth factor C (VEGFC), a major inducer of angiogenesis, has been specifically shown to correlate with poor prognosis, tumour progression, and metastasis of NSCLC (Zhang et al, 2007; Wang et al, 2009).