In the context of suppressing u-PAR gene expression through Enz, it was an interesting initial observation in our study that the knockdown of u-PAR might be able to resensitise relatively resistant NSCLC cells and induces apoptosis after Enz treatment (Querfeld et al, 2006; Lee et al, 2008; Morgillo et al, 2008). This evidence concerns the gene PLAUR and non-small cell lung carcinoma.