Genes promoting cancer progression (u-PAR, VEGFC, and HIF1α) and tumour suppression (VHL, RASSF1, and FHIT) of NSCLC were significantly (P<0.05) down- or upregulated after Enz treatment in H460, A549, and H1299 cells, respectively. This evidence concerns the gene RASSF1 and neoplasm.