Gudmundsson et al (1995) and Grönberg et al (2001) have reported LOH in PrCa patients. Gudmundsson et al (1995) investigated five high-risk breast cancer families and found seven men with PrCa, six of whom had LOH at the BRCA2 locus. Grönberg et al (2001) studied a breast/prostate family (three breast cancer, five PrCa) that was found to have a deleterious BRCA2 mutation (6051delA). This evidence concerns the gene BRCA2 and breast cancer.