The IMPACT study (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1 and BRCA2 mutation carriers and controls) has been developed to investigate the role of targeted PrCa screening in male BRCA1 and BRCA2 gene mutation carriers using an annual PSA screen (Mitra et al, 2007). The gene discussed is BRCA1; the disease is prostate cancer.