Schneiderhan et al (2009) further confirmed that CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vitro and in vivo models. MCT1 inhibition has also been shown to have anti-tumour potential against in vivo models of lung carcinoma, colorectal carcinoma and a squamous carcinoma cell line after α-cyano-4-hydroxycinnamate-mediated MCT1 inhibition (Sonveaux et al, 2008). The gene discussed is BSG; the disease is familial pancreatic carcinoma.