CD147 (EMMPRIN, extracellular matrix metalloproteinase inducer protein) is a multifunctional glycoprotein that can modify the tumour microenvironment by activating proteinases, inducing angiogenic factors in both tumour and stromal cells, and regulating growth and survival of anchorage-independent tumour cells (micrometastases) and MDR expression (Yan et al, 2005). The gene discussed is BSG; the disease is neoplasm.