Castells et al (2000) showed that a deletion on chromosome 22q13 is involved in breast and colorectal cancer and suggested the existence of tumour suppressor genes within this region (Castells et al, 2000). Moreover, Mongroo et al (2004) showed that ParvB inhibits ILK-mediated signalling and that ParvB is downregulated in advanced breast cancer. The gene discussed is PARVB; the disease is breast cancer.