It has also been shown that lysosomal dysfunction accompanies α-synuclein aggregation in a progressive toxic mouse model of PD [94], and that mutations in ATP13A2, another PD-associated gene encoding a lysosomal ATPase, lead to defective autophagy and aggregation of α-synuclein in PD [95], [96]. This evidence concerns the gene ATP13A2 and Parkinson disease.