In the present study, we examined the expression of survivin, p53, and pERK1-2 proteins as well as the amplification of CyclinD1 and h-prune genes in a well-characterized cohorts of patients with T4 breast carcinoma and a long follow-up, in order to determine their association with clinical and pathological parameters as well as with patients' outcome. The gene discussed is BIRC5; the disease is breast carcinoma.