Moreover, a genomic instability with an increased number of copies of the CyclinD1 gene, which encodes a component of the p16CDKN2A-RB pathway functionally interacting with the MAPK pathway [12,13], has been described to promote a deregulation of the cell cycle with subsequent induction of an uncontrolled cell proliferation and tumour growth [14]. Here, CCND1 is linked to neoplasm.