To evaluate the pathogenetic and prognostic roles of five candidate molecular markers (expression levels of survivin, p53, and pERK1-2 proteins; amplification of CyclinD1 and h-prune genes), we have examined fifty-three patients with diagnosis of T4 breast carcinoma (T4-N0-2-M0, according to the TNM classification by Sobin et al. [1]). The gene discussed is PRUNE1; the disease is breast carcinoma.