No statistically significant correlation between any of the molecular alteration and pathological parameters was observed (including triple negative tumours: ER-, PR-, HER2-), with the exception of the detection of positive pERK1-2 immunostaining in the group of patients negative for Ki67 expression only [the pERK1-2 expression was not detected in tumours expressing Ki67 (0/16), whereas 4/26 (15%) Ki67+ tumours presented a positive pERK1-2 immunostaining; p = 0.041] (Table 2). The gene discussed is ESR1; the disease is neoplasm.