In-vivo, MDA-7 mediated tumour specific apoptosis has been demonstrated to be supplemented by an additional 'anti-tumour bystander' effect, with the former 'intra-cellular killing' being receptor-independent and the latter dependent on MDA-7 secretion and canonical IL-20/IL-22 receptor complexes on the surface of target cells [14,15,19,22]. This evidence concerns the gene IL20 and neoplasm.