Another relevant member of the top 40 list of genes was HUWE1, a pleitropic ubiquitin ligase that participates in a wide variety of biological functions related to cell proliferation such as cell growth/death, and DNA replication, and that has been described to be deregulated in different carcinomas [61] (see Figure 8 and Table 4). This evidence concerns the gene HUWE1 and carcinoma.