Common up-regulation of genes such as COL1A1, COL1A2, PGF, LRRFIP1, TMEFF2 or TGFB1 suggested an important role of this pool of cells in blood vessel formation, angiogenesis, permeability and proliferation pathways, essentials functions in tumour progression [38-40] (Figure 5). Here, TMEFF2 is linked to neoplasm.