Significantly, most of these up-regulated genes encoded secreted proteins involved in autocrine and paracrine signalling, like TGFBI, a pleiotropic cytokine that, among other functions, can induce the dissociation of VE-cadherin junctions between endothelial cells which could favour mature tumour or GBM cells migration [43]. The gene discussed is CDH5; the disease is glioblastoma.