Genes in this set include: DARC, TNXB, CCL14, LDB2, LHFP, and C7. Duffy antigen receptor for chemokines (DARC) is believed to suppress tumor metastasis through two mechanisms: by sequestering angiogenic chemokines [88,89] and by inducing KAI1/CD82 tetraspandin in tumor cells, thereby causing senescence [90-92]. The gene discussed is ACKR1; the disease is neoplasm.