The activity of a single TF may profoundly change the tumor cell phenotype, as for example, RNAi-mediated knockdown of Klf17 (Krüppel-like factor) promotes EMT and lung metastasis of 168FARN cell line, whereas overexpression of Klf17 in the metastatic 4T1 cell line considerably limits their metastatic potential [73]. The gene discussed is TF; the disease is neoplasm.