The induction of multi-drug resistance in tumor cells was caused by factors such as P-gp [9], MRP, LRP, GST, glutathione, glutathione S-transferase, protein kinase C, apoptosis-related gene (bcl-2, c-myc, p53), and the high-expression of GCS in the cancer cell living environment and variation of DNA type II topoisomerase activity [10-17]. The gene discussed is TP53; the disease is cancer.