highly similar molecules found to be antagonists of GPCR GPR7 (associated with feeding behavior, obesity and inflammatory pain); CYP2C9 (metabolizes NSAIDS and sulfonylureas); inhibition of Non small-cell lung cancer (NCI HOP-18) and supression of colon tumors; inhibition of HIV-1 RNase H. The gene discussed is NPBWR1; the disease is colonic neoplasm.