C2 and hyperinsulinemic hypoglycemia, familial, 4: The fact that we were able to show normalization of complement activation at concentrations of rhC2 (3-6 μg/mL) that are lower than those typically observed in normal human serum (16-40 μg/mL) is in accordance with the reports that the heterozygous C2-deficiency state is not a risk factor for disease [3], and confirms that the rhC2 is fully functional.