HIF1α levels were significantly up-regulated in and around tumour tissue at 20W (p < 0,001), 25W (in: p < 0,001; around: p < 0,05) and 30W DEN (p < 0,001) compared to adjacant non-HCC tissue (figure 6 and 7). Here, HIF1A is linked to hepatocellular carcinoma.