37). Moreover, transgenic expression of LIP in mammary glands resulted in hyperplasia and tumorigenesis in mice, suggesting a pro-proliferative and tumorigenic potential of the LIP isoform 59. In several model systems the rapamycin-mediated inhibition of mTOR altered the isoform ratio in favor of LAP and resulted in a decrease in tumor cell proliferation 58, 60, 61. The gene discussed is CEBPB; the disease is neoplasm.