NME1 and neoplasm: Among them, there are both microenvironment-dependent regulators of tumour initiation, progression and metastasis like TGFβ that has diverse and often conflicting roles in tumour progression [27] and tumour- and metastasis-suppressor gene SYK [23], metastasis suppressor gene NME1 [28] and metastasis-associated gene S100A4 (MTS1, metastasin) [29].