TREM2 and Nasu-Hakola disease: Interestingly, loss-of-function mutations of DAP12 or TREM2 both lead to a chronic neurodegenerative disease called Nasu-Hakola or polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), an autosomal recessive inherited disease [18].