Therefore, the aims of this study were to evaluate infection in B10.A and A/J mice (both H-2a), compare the survival rate and tissue lesions, and analyze the proliferative response and production of IFN-γ and IL-10 in cultures of spleen cells from normal and immunized mice stimulated with the crude extract of the parasite (CE) or concanavalin A (ConA). This evidence concerns the gene IL10 and infection.