In experimental paracoccidioidomycosis, B10.A mice behave as susceptible and A/J as resistant strain to fungal infection, that correlates with differences in the immune response, since resistant mice showed prevalent type 1 immunity whereas susceptible B10.A presented a progressive form of infection with impaired IFN-γ secretion [18, 19]. Here, IFNG is linked to paracoccidioidomycosis.