Moreover, IDO-1 is an inducible enzyme, activated in AD by proinflammatory cytokines, such as interferon-gamma (IFN-γ) [6], interleukin-12 (IL-12), interleukin-18 (IL-18) [7], and the Aβ 1-42 fragment [8]. The gene discussed is IDO1; the disease is Alzheimer disease.