TNK2 and Ewing sarcoma: Of the 16 significant gene hits that modulated the growth and proliferation of Ewing's sarcoma cell lines, two genes STK10 (serine threonine kinase 10) and, TNK2 (tyrosine kinase, non- receptor, 2) were prioritized for further confirmation since both siRNAs targeting these genes were hits across all four Ewing's sarcoma cell lines (Figure 1).