SP110 and disease arising from reactivation of latent virus: We utilized a real-time PCR assay to measure the expression of mRNA encoding Coronin-1, Sp110 and TLRs in fresh whole blood cells of TB patients, close contacts to patients that had latent infection (Quantiferon positive, QFT (+)), close contacts to patients with no latent infection (Quantiferon negative, QFT (-)) and a negative control population.