It was recently reported that Sp110 expression promotes the replication of intracellular pathogens, as in A. phagocytophilum, an obligate intracellular tick-borne pathogen that causes human granulocytic anaplasmosis (HGA) in HL-60 cells, while silencing of Sp110 expression by RNA interference results in decreased levels of infection [53]. Here, SP110 is linked to human granulocytic anaplasmosis.