PTGS2 and colonic neoplasm: Cyclooxygenase-2 is overexpressed in colon tumour tissues (Eberhart et al, 1994; Sano et al, 1995) and contributes to CRC progression and malignancy through mechanisms that act on cell proliferation/invasion (Yamauchi et al, 2002; Strillacci et al, 2006), apoptosis inhibition (Tsujii and DuBois, 1995) and tumour angiogenesis (Spisni and Tomasi, 1997; Iñiguez et al, 2003).