As it is well known that bacterial LPS induces COX-2 expression in human cells and, as we show herein, InvColi-pS− infection at an MOI 1:100 induces COX-2 overexpression in CRC cells, our hypothesis is that the survival of CRC cells after bacterial infection could be strictly dependent on COX-2 induction. This evidence concerns the gene PTGS2 and colorectal carcinoma.