It is commonly accepted that COX-2 can contribute to CRC development and progression through mechanisms involving the stimulation of angiogenesis (Spisni and Tomasi, 1997; Iñiguez et al, 2003), the inhibition of apoptosis (Tsujii and DuBois, 1995) and the increase in cell migration/invasiveness (Yamauchi et al, 2002; Strillacci et al, 2006). This evidence concerns the gene PTGS2 and colorectal carcinoma.