IGFBP3 and liver cancer: Although there was no evidence of a nonlinear relation (P=0.38 for quadratic term) between the IGF-I/IGFBP-3 molar ratio and risk, there was a suggested linear association such that for every 0.05-unit decrease in molar ratio, the odds of developing liver cancer increased by a factor of 1.35 (=1.0/0.74), after adjustment for age, daily cigarettes, and physical activity (OR=0.74; 95% CI=0.53–1.01), but this was not significant (P=0.06).