CD177 and Familial prostate cancer: Subsequent studies revealed several important insights regarding XMRV: (a) infectious virus was produced from prostate cancer cell lines transfected with an XMRV genome derived from 2 cDNA clones, (b) the virus replicated in both prostate and non-prostate cell lines, (c) XMRV replication in the prostate cancer-derived cell line, DU145, is interferon sensitive, and (d) a human cell surface receptor required for infection with XMRV is xenotropic and polytropic retrovirus receptor 1 [2].