Mutations in α-synuclein located on PARK1 and PARK 4, Parkin, Ubiquitin carboxy-terminal-hydrolase-L1(UCHL1), PTEN-induced-putative kinase (PINK1), DJ1, Leucine-rich repeat kinase 2 (LRRK2), ATPase type 13A2 (ATP13A2), HTRA2 genes in PARK2, 5, 6, 7, 8, 9 and 13 have been shown, respectively, to cause PD [14]. This evidence concerns the gene PRKN and Parkinson disease.