THBS1 and hepatocellular carcinoma: Immunoreactivity to VEGF-A, bFGF, TGF-β, MCP-1, TSP-1, TIMP-1, TIMP-2, and endostatin was observed mainly in HCC cells and hepatocytes, showing a predominant cytoplasmic staining with positive liver cells distributed throughout the tumor tissue and the surrounding liver (Figures 1 and 2).