Although many cell types can produce CCL2, we found that Ccl2 gene expression was induced in liver CD11b+Ly6C+ monocytic cells during infection and further upregulated upon IL-10 neutralization, suggesting that IL-10 negatively regulates a CCL2 dependent positive feedback loop for liver CD11b+LyC6+ monocyte recruitment. This evidence concerns the gene ITGAM and infection.