INS and type 2 diabetes mellitus: Finally, to test whether mitochondrial dysfunction may be causal to T2D, we applied MAGENTA to a set of known nuclear regulators of mitochondrial genes [35], the OXPHOS genes [9], and all known (∼1,000) autosomal human mitochondrial genes [22], using the latest T2D meta-analysis of a total of 47,117 individuals (DIAGRAM+) [36], as well as meta-analyses (up to 46,186 individuals) of seven glucose and insulin-related traits relevant to T2D pathogenesis (MAGIC; [37], [38], Soranzo N. et al., unpublished data).