While specific genes ranked high among the 16 regulators (but not at gene-wide significance), such as GABPA (the GA binding protein transcription factor, alpha subunit) [50] with respect to T2D associations or SIRT1 (sirtuin, silent mating type information regulation 2 homolog 1; Entrez ID 23411) [51], [52] with respect to fasting insulin levels and measures of insulin resistance and ß-cell function, our statistical tests do not constitute a proof of their involvement in T2D. The gene discussed is SIRT1; the disease is type 2 diabetes mellitus.