In this work we investigated the cytotoxic and apoptotic effect of chalcones: (C1) chalcone, (C2) 2’6’-dihydroxy-4’-methoxychalcone and dihydrochalcones: (C3) 2’6’-dihydroxy-4’-methoxydihydro-chalcone, (C4) 2’,6’-dihydroxy-4,4’-dimetoxydihydrochalcone, (C5) 4,2’,4’,6’-tetrahydroxydihydro-chalcone (named phloretin) in combination with TRAIL on prostate cancer cells. Here, TNFSF10 is linked to Familial prostate cancer.