Jespersen et al in a cross sectional study among normal and overweight non-diabetic individuals showed that those with high value of TC/HDL-C were more resistant to insulin-stimulated glucose disposal, and to had higher blood pressure, increased TG concentrations, and hyperinsulinemia [27], rendering these individuals at increased risk of coronary heart disease and possibly diabetes for reasons unrelated to cholesterol metabolism. This evidence concerns the gene INS and hyperinsulinism.