The constitutive activation of STAT3 is frequently detected in primary human colorectal carcinoma cells and established human colorectal cancer cell lines [2,3,20,21] and elevated levels of STAT3 phosphorylation have been correlated with tumor invasion, nodal metastasis, and staging (P < 0.05) [3,20]. This evidence concerns the gene STAT3 and colorectal carcinoma.