The positive rate of ERα expression in breast ductal hyperplasia was summarized in Table 2.The positive rate of ERα expression was lower in ADH (118/136, 86.8%) than that in UDH (79/79, 100%) (P < 0.001), but higher than that in DCIS (28/41, 68.3%) or IDC (26/45, 57.8%) respectively (P < 0.001). This evidence concerns the gene ESR1 and hyperplasia.