We found that none of the three SNPs showed significant influence on OS, except for the CT genotype of VEGF -460 T > C SNP, which was marginally associated with increased OS in NSCLC patients of stage IIIb (adjusted HR = 0.56; 95% CI, 0.30-1.05, P = 0.071 and other data not shown). The gene discussed is VEGFA; the disease is non-small cell lung carcinoma.