In addition, among such patients with severe disease, those with monocytes exhibiting high ICAM-1 expression may co-localize monocytes to parasitized red cells adherent to brain endothelium contributing further to the lesion of cerebral malaria, while in contrast, patients with low monocyte ICAM-1 may have less co-localization and reduced risk of cerebral malaria[12]. The gene discussed is ICAM1; the disease is cerebral malaria.