Loss of MTSS1 expression occurred more frequently in large gastric tumors (invasion to level T3-T4) (76.1%) than in small ones (level T0-T2) (55.4%; P < 0.001) and more frequently in gastric tumors with regional LN metastasis (76.3%) than in N0-stage tumors (57.6%; P < 0.001). This evidence concerns the gene MTSS1 and gastric neoplasm.