TLR4 and asthma: Given that some prior studies, often with an n of 20–100, demonstrated an association between TLR4 polymorphisms and LPS hyporesponsiveness or clinical outcomes of airway dysfunction such as asthma and bronchiolitis [14], [26], [31], [32], we conducted subanalyses of genotype and intermediate phenotype based on stratification by (i) current asthma (Figure 2) or a prior clinical history of bronchiolitis in the first two years of life (Figure 3).