TAX1BP3 and neoplasm: Although further investigation is needed to elucidate the mechanism(s) by which X-ray irradiation induces the TIP-1 translocation onto the cell surface and the biological relevance of the TIP-1 translocation in the tumor response to radiation, we revealed that the cells responding to radiation by relocating TIP-1 onto the cell surface are live but have reduced capability to proliferate and form colonies.