Despite the decreased DbNPN3A+CD8+ T cell numbers generated following primary infection (Fig 2A–C), the recall response was substantial following HKNPN3A challenge of PRNPN3A-immune mice (Fig 2DE) and the NP>PA immunodominance hierarchy that has long been recognized for secondary responses to wt influenza A viruses in H2b mice [25] was maintained (Fig 2DE). This evidence concerns the gene CD8A and infection.