As well as their roles in determining cell fate, survival, and growth in Drosophila (for review, see Affolter and Basler, 2007), TGF-β superfamily signals regulate tissue morphogenesis and have been shown to influence the invasive behavior of metastatic tumors (for review, see Leivonen and Kahari, 2007; Wu and Hill, 2009). Here, TGFB1 is linked to metastatic neoplasm.