The reduction of immunoreactive signal specific for the desmosomal proteins DSP, PG, and PKP2 from cardiac intercalated disks in two individuals with the DSG2 G812S mutation (Figure 2), but not in the mouse model, may potentially be explained by differences between murine ARVC models and human disease. This evidence concerns the gene PKP2 and arrhythmogenic right ventricular cardiomyopathy.