Moreover, the gap junction remodeling observed in the endomyocardial biopsy samples (indicated by reduced immunoreactive signal for Cx43, Figure 2) may act synergistically with the histologic abnormalities characteristic of ARVC to enhance conduction heterogeneity and increase the risk of arrhythmia.7 This evidence concerns the gene GJA1 and Arrhythmogenic right ventricular dysplasia.