Direct sequencing using DNA samples from 94 hypertension subjects revealed sixteen SNPs in the FURIN gene, including two SNPs in the promoter region, one SNP in the 5'-untranslated region, five synonymous mutations in exon 13 and exon 16, four SNPs in the 3'-untranslated region, and five SNPs in introns (Table 2). Here, FURIN is linked to hypertensive disorder.