The human 5q22.2 and 18q21.1-q21.2 regions are both constantly disrupted in human CRCs [15,16], and encode bona fide CRC driver genes (e.g., APC, SMAD4) as well as genes whose role in cancer etiology remains unclear (e.g., mutated in colorectal cancer or MCC). This evidence concerns the gene SMAD4 and colorectal carcinoma.