SMAD2 and colorectal carcinoma: Besides genes of 5q22.2 and 18q21.1-q21.2 described above, we also investigated genes with high mutation prevalence (i.e., P53, KRAS, and PIK3CA), as well as those with intermediate-low mutation prevalence (i.e., SMAD2 and SMAD3) in human CRC [46].