link genetic desmosomal abnormalities to the presence of fat in the right ventricle of ARVC patients, due to dysfunction of PPARγ and α. Suppressing DSP expression leads to nuclear translocation of the desmosomal plakoglobin (or γ-catenin) by disruption of weakened desmosomes. This evidence concerns the gene PPARG and arrhythmogenic right ventricular cardiomyopathy.