In a recent study, Djouadi et al. [11] have shown for the first time that RV surviving myocytes from ARVC was characterized by a reduction in expression of PPARα, as compared to control hearts, together with a dramatic activation of the PPARγ pathway, as attested by the increase in PPARγ mRNA and protein. The gene discussed is PPARG; the disease is Arrhythmogenic right ventricular dysplasia.