PPARA and hyperlipidemia: Exogenous agents that alter PPAR signaling in the adult, such as environmental agents, chemicals, or drugs, are capable of affecting lipid and glucose utilization, cholesterol biosynthesis, and other metabolic pathways, and these attributes make PPAR signaling an attractive target for pharmaceuticals directed at management of disease states (diabetes, metabolic syndrome, hyperlipidemia) [4, 40].