The significant role of cytokines, such as TNF-α, IL-6, IL-8, IFN-gamma, IL-1, and IL-17 in the generation of proatheromatous abnormalities (dyslipidemia, insulin resistance, endothelial dysfunction, clotting system activation, and pro-oxidative stress) was reported [127, 128, 146, 147]. The gene discussed is TNF; the disease is Insulin resistance.