In a previous study, Monetti et al.[32] report that various lipids, including TG, DAG and ceramides, accumulated in mouse liver as a result of overexpression of acyl-CoA:diacylglycerol acyltransferase (DGAT) but without associated insulin resistance, and they concluded that hepatic steatosis could ensue independently of insulin resistance. Here, DGAT1 is linked to fatty liver disease.