SLC2A1 and neoplasm: However, mTOR inhibitors (e.g., temsirolimus) are able to reduce glucose uptake in tumors [96] (e.g., kidney cancer), although this effect is probably related to the inhibition on tumor angiogenesis (inhibiting the mTOR-dependent HIF1/VEGF signaling) and glucose deprivation of tumor, rather than with a possible direct effect of mTOR pathway on GLUT expression and/or trafficking.